We are looking for an outstanding Senior Postdoctoral Scientist/Deputy Group Leader (Immunology) to join the research group of Assoc. Prof. Dr. Kaan Boztug at the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD) in Vienna, Austria. Together with the Lab Head and Director of LBI-RUD, Kaan Boztug, you will be leading defined projects focusing on deciphering the molecular basis of human immune dysregulation, and contribute to coordination and advancement of the group’s research projects. The successful candidate will work within the framework of the newly ERC-funded “iDysChart” project.
iDysChart – Charting key molecules and mechanisms of human immune Dysregulation
Failure/disorders of the immune system to protect itself can result in autoimmunity and autoinflammation as observed in many human diseases. This interesting project aims at i) identifying novel monogenic causes of autoimmune/autoinflammatory diseases, enabling elucidation of fundamental mechanisms, ii) creating a network-level understanding of molecular pathways of immune dysregulation and iii) employing chemical and genetic screens to complement human disease gene discovery in predicting the core human immune dysregulome and investigating potential avenues for therapeutic modulation.
Previous projects of our working group have already led to the identification of novel disease-causing genes in patients with autoimmune disorders (van Rijn et al., Gastroenterology 2018; Ozen et al., NEJM 2017; Salzer et al., Nat Immunol 2016; Dobbs et al., NEJM 2015).
The iDysChart project will particularly focus on deciphering key principles of human autoimmunity and autoinflammation by studying model diseases including very early-onset IBD, monogenic autoimmune disorders, such as systemic lupus erythematodes (SLE), and systemic autoinflammatory disorders.
The research group/institute
Assoc. Prof. Dr. Kaan Boztug is a leading immunologist and rare diseases researcher and director of the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD). Recently, he received a prestigious
ERC Consolidator Grant with a project duration of five years to decode disorders of the human immune regulation.
Our research focuses on the identification of rare monogenic disorders of the immune system and hematopoiesis to explain pathophysiological manifestations in humans. In the context of this work, we apply a combination of state-of-the-art genetic and genomic technologies including next generation sequencing, and a wide range of cellular and molecular techniques to elucidate novel pathways important for immune system homeostasis.
The group works in a fully equipped molecular biology laboratory in a shared environment with cell culture, multi-color flow cytometry, as well as all equipment needed for state-of-the-art genomic investigations such as SNP arrays and deep sequencing, which are immediately accessible in-house.